- Sandwich Shop Restaurants, Roanoke
- Scrap & Waste Materials, Roanoke
- Screen Printing, Roanoke
- Secondary Schools, Roanoke
- Security Brokers & Dealers, Roanoke
- Septic Tank Installation & Repair, Roanoke - Septic Systems
- Septic Tank Pumping & Cleaning, Roanoke - Septic Systems
- Septic Tanks & Septic Systems Contractors, Roanoke - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewer & Drain Cleaning & Repair, Roanoke - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Roanoke - Sewer Line, Pipe Installation & Repair Services
- Sewing & Yarn Stores & Supplies, Roanoke
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- Shooting & Target Ranges, Roanoke
- Shopping & Shopping Services, Roanoke
- Snow Removal Services, Roanoke - Snow Plow Service
- Social Services & Welfare, Roanoke
- Special Dies Tools Jigs & Fixtures Manufacturers, Roanoke
- Speciality Food Stores, Roanoke
- Specialty Animal Services, Roanoke
- Specialty Stores, Roanoke
- Stocks & Bond Brokers, Roanoke
- Stoves & Furnace Equipment, Roanoke - Fittings & Repair Parts
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