- Obstetricians & Gynecologists, Mooresville - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Mooresville
- Off Road Vehicles Parts & Accessories, Mooresville
- Oil & Petroleum Products, Mooresville - Merchant, Wholesalers, etc
- Oncologists, Mooresville - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Mooresville - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Repair & Service, Mooresville - Camera Repair
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Mooresville
- Opticians, Mooresville
- Optometrists, Mooresville - Eye Doctors, Physicians & Surgeons (Optometry)
- Orchard Equipment, Mooresville
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- Orchard Service, Mooresville
- Ornamental Nursery, Mooresville
- Ornamental Nursery Services, Mooresville
- Orthodontist, Mooresville - Teeth Straightening, Invisalign & Dental Braces
- Orthopedists, Mooresville - Orthopedic Surgery Doctors, Physicians & Surgeons
- Osteoporosis Doctors, Mooresville - Physicians & Surgeons
- Other Building Materials & Supplies, Mooresville
- Otolaryngologists, Mooresville - Ear, Nose, Throat - ENT Doctors, Physicians & Surgeons (Otolaryngology)
- Outdoor & Lawn & Garden Equipment Repair & Service, Mooresville
- Outdoor Equipment & Accessories, Mooresville
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