- Sand Gravel & Aggregate, Mooresville
- Sandwich Shop Restaurants, Mooresville
- Satellite Dish Antennas & Equipment Dealers, Mooresville
- Sawmill & Planing Mills, Mooresville
- Sawmill Supplies & Equipment Repair, Mooresville
- Scaffolding & Aerial Lifts, Mooresville
- Scientific & Laboratory Equipment & Instruments, Mooresville
- Seafood Restaurants, Mooresville
- Secondary Schools, Mooresville
- Security Brokers & Dealers, Mooresville
- Senior Citizens Service & Health Organizations, Mooresville
- Septic Tank Installation & Repair, Mooresville - Septic Systems
- Septic Tank Pumping & Cleaning, Mooresville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Mooresville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewage Systems, Mooresville
- Sewer & Drain Cleaning & Repair, Mooresville - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Mooresville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Mooresville
- Shopping & Shopping Services, Mooresville
- Shore, Lake & Pond Maintenance & Treatment, Mooresville
- Siding Contractors, Mooresville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Mooresville
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- Smelters & Refiners Equipment & Supplies, Mooresville
- Smoking Cessation Treatment Centers & Information Services, Mooresville
- Snacks & Desserts, Mooresville
- Snow Removal Services, Mooresville - Snow Plow Service
- Social Services & Welfare, Mooresville
- Special Coatings, Mooresville - Protective Coatings
- Special Dies Tools Jigs & Fixtures Manufacturers, Mooresville
- Special Interest Schools Or Instruction, Mooresville
- Specialty Stores, Mooresville
- Speech & Hearing Specialists, Mooresville
- Sporting Goods Stores, Mooresville
- Sprinkler System Contractors, Mooresville - Garden & Lawn Sprinkler System Installation & Repair
- Staffing & Support Services, Mooresville
- State Government, Mooresville
- Steel & Metal Goods, Mooresville - Steel Distributors
- Steel Manufacturers, Mooresville
- Stocks & Bond Brokers, Mooresville
- Submarine Sandwich Restaurants, Mooresville
- Substance Abuse Outpatient Clinics, Mooresville
- Surveyor Services, Mooresville - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Mooresville
- Swimming Pools Supplies, Equipment & Accessories, Mooresville
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